Understanding Post-Acute Sequelae of SARS-CoV-2 Infection (PASC): The Weird Taste Syndrome
Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), often referred to as Long COVID, describes various symptoms persisting for weeks or even months following the acute phase of the COVID-19 illness. These effects can impact any organ system within the body, with prevalence rates varying widely across different studies due to varying study designs. A common symptom among many PASC patients is the alteration in taste, frequently described as a lingering unusual or weird taste in the mouth.
The exact reasons why SARS-CoV-2 leads to this enduring taste distortion, known as dysgeusia, are still under investigation. Hypotheses include:
- Direct viral damage to gustatory cells.
- Inflammation of the taste pathways.
- Indirect effects from other systemic symptoms of COVID-19.
While the spectrum of PASC symptoms is wide, the persistent alteration in taste in some COVID-19 survivors serves as a stark reminder of the virus’s profound and potentially long-lasting impact on the human body, extending far beyond the initial infection phase.
Possible Causes of Altered Taste Sensation After COVID-19 Recovery
This could include:
- Direct Viral Damage: The SARS-CoV-2 virus may cause damage to the cells responsible for smell and taste (olfactory and gustatory cells). This damage could occur either through direct infection of these cells or the indirect effects of systemic inflammation caused by the body’s immune response to the virus.
Cytokine Storm: Another possibility is the ‘cytokine storm,’ a powerful and uncontrolled release of pro-inflammatory molecules that the virus can trigger. This intense inflammatory response could potentially impact the nervous system.
- Medications: Certain medications used to treat COVID-19 could also potentially contribute to taste alterations. These medications may alter the oral microbiome or directly impact the function of taste receptors. People who get what’s called a “Paxlovid mouth” often notice a bitter or metallic taste shortly after taking their first set of pills.
- Mental Health Impact: The mental health impacts of COVID-19, such as anxiety and depression, could indirectly contribute to an altered sense of taste.
It’s important to note that these are current hypotheses based on our understanding, and further research is needed to confirm these theories and potentially uncover additional causes.
The Science Behind Taste Dysfunction: How COVID-19 Can Impact the Taste Buds
COVID-19 has been shown to impact taste buds in various ways, leading to conditions like dysgeusia (distorted sense of taste) or ageusia (loss of taste). Here’s a deeper dive into how it may happen:
- Direct Invasion of Cells: The SARS-CoV-2 virus, which causes COVID-19, uses a spike protein on its surface to bind to the ACE2 receptor in human cells. This receptor is found in many parts of the body, including the oral cavity and tongue, which house our taste buds. By directly infecting these cells, the virus could potentially cause damage or changes that lead to taste disturbances.
Impact on the Nervous System: Taste sensation relies on a complex network of nerves to transmit signals from the taste buds to the brain. If the virus, or the body’s inflammatory response to it, impacts these nerves, it could disrupt this signal transmission, leading to changes in taste perception.
- Cytokine Storm: In severe cases of COVID-19, the immune system can overreact, leading to a ‘cytokine storm’—a flood of inflammatory molecules. This excessive inflammation could potentially damage tissues and organs, including those involved in taste sensations.
- Interaction with Saliva: Our sense of taste also depends on saliva, which helps dissolve food particles and carries them to the taste buds. Some evidence suggests that COVID-19 might alter salivary glands’ function, which could, in turn, impact taste.
- Recovery and Regeneration: Taste buds typically regenerate every 10 to 14 days. However, if COVID-19 disrupts this process, it might lead to a prolonged loss or taste alteration.
Medical Interventions and Self-Care Strategies to Combat the Weird Taste in Mouth After COVID-19
Several strategies and interventions address the symptom of altered taste sensation after COVID-19 recovery. However, please consult a healthcare provider for the most updated and personalized advice.
Medical Interventions:
- Medication: Depending on the underlying cause, certain medications may be prescribed to help restore taste. This can include corticosteroids to reduce inflammation or other medicines for nerve health.
- Zinc Supplementation: Zinc deficiency has been linked with taste disturbances, so some healthcare providers may recommend zinc supplements. However, this should only be done under medical supervision.
- Physical Therapy: In some cases, physical therapy designed for the mouth and tongue may be beneficial. This can involve exercises designed to stimulate the taste buds and nerves involved in taste sensation.
Self-Care Strategies:
- Maintain Oral Hygiene: Regular brushing, flossing, and use of mouthwash can help maintain a clean oral environment, which may help improve the metallic taste over time. Avoiding mouthwashes that contain alcohol. If you find cooking smells affect your hunger, you could try microwavable meals that need heating up or eat cold food such as sandwiches or salad.
- Hydration: Staying well-hydrated is important, especially if a dry mouth contributes to taste changes.
Dietary Adjustments: Experiment with different foods, spices, and flavors to see what tastes best. Sometimes, strongly flavored foods like citrus fruits, mint, or ginger can be more appealing and stimulate taste sensation. Eating cold foods also reduces the metallic taste, and chewing sugar-free gum and sour-tasting drops.
- Quit Smoking: If you’re a smoker, quitting can improve your sense of taste. COVID-19 recovery is an excellent opportunity to enhance overall health by stopping smoking.
- Stress Management: As there may be a psychological component to taste disturbances, stress management techniques such as mindfulness, meditation, and yoga can be beneficial.
Remember, if you’re experiencing a prolonged weird taste in your mouth after COVID-19, you must reach out to a healthcare professional. They can guide you through the best action based on your case and the latest research findings.
References:
https://ada.com/covid/covid-19-symptom-metallic-taste/
https://www.yourcovidrecovery.nhs.uk/i-think-i-have-long-covid/effects-on-your-body/taste-and-smell/
https://health.clevelandclinic.org/common-causes-for-metallic-taste-in-your-mouth/
https://naomedical.com/blog/weird-taste-in-mouth-after-covid/
http://www.phsa.ca/health-info-site/Documents/post_covid-19_Taste_and_Smell_Changes.pdf
https://www.everydayhealth.com/coronavirus/top-covid-19-symptoms-have-changed-study-finds/
https://www.medicalnewstoday.com/articles/paxlovid-mouth-what-is-it-and-how-to-get-rid-of-it